Ignatova T M, Chernova O A, Gaĭdasheva E V
Klin Med (Mosk). 2012;90(5):64-6.
This clinical observation demonstrates successful rituximab therapy of HCV-cryoglobulinemic vasculitis with severe ulcerative and necrotic lesions of the skin on the lower extremities. Vasculitis recurred 3 years after the persistent virological response had been achieved and complete clinical remission resulted from antiviral therapy. Possible causes of vasculitis relapses in the absence of HCV viremia are discussed with reference to the difficulties encountered in managing this condition.
该临床观察表明，利妥昔单抗成功治疗了丙型肝炎病毒相关性冷球蛋白血症性血管炎，患者下肢皮肤出现严重溃疡性和坏死性病变。在实现持续病毒学应答3年后血管炎复发，抗病毒治疗使临床完全缓解。本文结合治疗该疾病时遇到的困难，讨论了在无丙型肝炎病毒血症情况下血管炎复发的可能原因。
