Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27715, USA.
Curr Cardiol Rep. 2012 Feb;14(1):49-58. doi: 10.1007/s11886-011-0233-y.
Proton pump inhibitors and clopidogrel are commonly prescribed medications, both alone and in combination. In January of 2009 the US Food and Drug Administration and the European Medicines Agency issued warnings with regard to the concomitant use of clopidogrel and proton pump inhibitors. Later that year, these warnings were limited to the proton pump inhibitor omeprazole. These warnings were largely based on in-vitro studies and observational analyses suggesting decreased efficacy of clopidogrel in the presence of proton pump inhibitors. Recent literature has suggested there may not be a clinically meaningful interaction.
质子泵抑制剂和氯吡格雷都是常用的处方药，单独使用或联合使用均可。2009 年 1 月，美国食品和药物管理局和欧洲药品管理局发布了关于氯吡格雷和质子泵抑制剂联合使用的警告。同年晚些时候，这些警告仅限于质子泵抑制剂奥美拉唑。这些警告主要基于体外研究和观察性分析，表明在质子泵抑制剂存在的情况下氯吡格雷的疗效降低。最近的文献表明，可能没有临床意义上的相互作用。
