染色体异常作为埃及复发性流产的一个原因。
Chromosomal abnormalities as a cause of recurrent abortions in Egypt.
作者信息
El-Dahtory Faeza Abdel Mogib
机构信息
Department of Genetics Unit of Children Hospital, Mansoura University, Mansoura, Egypt.
出版信息
Indian J Hum Genet. 2011 May;17(2):82-4. doi: 10.4103/0971-6866.86186.
Abstract
BACKGROUND
In 4%-8% of couples with recurrent abortion, at least one of the partners has chromosomal abnormality. Most spontaneous miscarriages which happen in the first and second trimesters are caused by chromosomal abnormalities. These chromosomal abnormalities may be either numerical or structural.
MATERIAL AND METHODS
Cytogenetic study was done for 73 Egyptian couples who presented with recurrent abortion at Genetic Unit of Children Hospital, Mansoura University.
RESULTS
We found that the frequency of chromosomal abnormalities was not significantly different from that reported worldwide. Chromosomal abnormalities were detected in 9 (6.1%) of 73 couples. Seven of chromosomal abnormalities were structural and two of them were numerical.
CONCLUSION
Our results showed that 6.1% of the couples with recurrent abortion had chromosomal abnormalities, with no other abnormalities. We suggest that it is necessary to perform cytogenetic in vestigation for couples who have recurrent abortion.
摘要
背景
在4%-8%的反复流产夫妇中，至少一方存在染色体异常。大多数发生在孕早期和孕中期的自然流产是由染色体异常引起的。这些染色体异常可能是数目异常或结构异常。
材料与方法
对在曼苏拉大学儿童医院遗传科就诊的73对埃及反复流产夫妇进行了细胞遗传学研究。
结果
我们发现染色体异常的发生率与全球报道的并无显著差异。在73对夫妇中，有9对（6.1%）检测到染色体异常。其中7例染色体异常为结构异常，2例为数目异常。
结论
我们的结果表明，6.1%的反复流产夫妇存在染色体异常，无其他异常。我们建议对反复流产的夫妇进行细胞遗传学检查是必要的。
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