Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
J Am Geriatr Soc. 2011 Oct;59(10):1908-12. doi: 10.1111/j.1532-5415.2011.03589.x. Epub 2011 Sep 13.
To examine whether concurrent depressive symptoms and self- and informant-reported cognitive impairments are related to cognitive complaints.
Longitudinal aging study of the relationship between depressive symptoms, reported cognitive impairments, and cognitive complaints. Mixed-effects regression models were used to determine whether scores on the Center for Epidemiologic Studies Depression Scale (CES-D) and Clinical Dementia Rating Scale (CDR) predicted cognitive complaints. The Cognitive Failures Questionnaire (CFQ) assessed cognitive complaints.
A community-dwelling sample in Baltimore, Maryland.
One hundred five cognitively normal older individuals with a mean baseline age of 75 followed for an average of 4 years.
The CES-D measured depressive symptoms. The CDR Sum of Boxes (CDR-SB) measured self- and informant-reported impairment, and the CFQ measured cognitive complaints.
Greater depressive symptoms and reported impairments are associated with higher CFQ scores. In addition, there was a significant interaction between depressive symptoms and reported impairment. Specifically, individuals without reported cognitive impairment had the strongest association between depressive symptoms and cognitive complaints. Finally, reported impairments interact with baseline age, suggesting that the relationship between reported impairments and cognitive complaints is strongest in individuals younger than 80.
These findings confirm a relationship between reported cognitive impairment and cognitive complaints in older individuals and highlight the extent to which age and depressive symptoms account for variation in complaints. These factors should be considered when interpreting cognitive complaints in a clinical setting.
探讨抑郁症状和自我报告及知情者报告的认知障碍是否与认知主诉相关。
抑郁症状、报告认知障碍与认知主诉之间关系的纵向老龄化研究。采用混合效应回归模型，确定流行病学研究中心抑郁量表（CES-D）和临床痴呆评定量表（CDR）评分是否预测认知主诉。认知失败问卷（CFQ）评估认知主诉。
马里兰州巴尔的摩的一个社区居住样本。
105 名认知正常的老年人，平均基线年龄为 75 岁，平均随访 4 年。
CES-D 测量抑郁症状。CDR 总评分（CDR-SB）测量自我报告和知情者报告的障碍，CFQ 测量认知主诉。
更多的抑郁症状和报告的障碍与更高的 CFQ 评分相关。此外，抑郁症状和报告的障碍之间存在显著的交互作用。具体来说，没有报告认知障碍的个体与抑郁症状和认知主诉之间的关联最强。最后，报告的障碍与基线年龄相互作用，提示报告的障碍与认知主诉之间的关系在 80 岁以下的个体中最强。
这些发现证实了报告的认知障碍与老年个体认知主诉之间存在关系，并强调了年龄和抑郁症状在解释认知主诉时的重要性。在临床环境中解释认知主诉时，应考虑这些因素。
