Zhang Ling-Ling, Li Ping, Li Yu-Min, Wang Ai-Qin
Lanzhou University Second Hospital, Lanzhou, China.
Drug Dev Ind Pharm. 2012 Jul;38(7):872-82. doi: 10.3109/03639045.2011.630397. Epub 2011 Nov 18.
The aim of this study was to use alginate-chitosan (Alg-CS) hydrogel beads for developing an oral water-soluble drug delivery system, occupying pH-sensitive property and superparamagnetic. Matrine as a model drug was loaded in Alg-CS hydrogel beads to study the release character of the delivery system. The amount of matrine released from the beads was relatively low in pH 2.5 over 8 h (34.90%), but nearly all of the initial drug content was released in simulated intestinal fluid (SIF, pH 6.8) within 8 h. The results demonstrated that Alg-CS hydrogel beads possess unique pH-dependent swelling behaviors. In addition, the magnetic beads were characterized by Fourier transform infrared spectroscopy, scanning electron microscope, X-ray diffractometry and vibrating-sample magnetometry. Magnetometer measurements data suggested that Alg-CS beads also had superparamagnetic property as well as fast magnetic response. It can be expected that the beads can deliver and release encapsulated anticancer agent at the tumor by the weak magnetic field, and hence could be potential candidates as an orally administered drug delivery system.
本研究的目的是使用藻酸盐-壳聚糖（Alg-CS）水凝胶珠来开发一种口服水溶性药物递送系统，该系统具有pH敏感性和超顺磁性。以苦参碱作为模型药物负载于Alg-CS水凝胶珠中，以研究该递送系统的释放特性。在pH 2.5条件下，8小时内从珠子中释放的苦参碱量相对较低（34.90%），但在模拟肠液（SIF，pH 6.8）中，8小时内几乎所有初始药物含量都被释放出来。结果表明，Alg-CS水凝胶珠具有独特的pH依赖性溶胀行为。此外，通过傅里叶变换红外光谱、扫描电子显微镜、X射线衍射仪和振动样品磁强计对磁珠进行了表征。磁强计测量数据表明，Alg-CS珠也具有超顺磁性以及快速磁响应。可以预期，这些珠子能够通过弱磁场在肿瘤部位递送并释放封装的抗癌药物，因此有可能成为口服给药递送系统的潜在候选者。
