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天然植物化合物苦参碱和氧化苦参碱在心血管疾病中的潜在治疗价值。

The potential therapeutic value of the natural plant compounds matrine and oxymatrine in cardiovascular diseases.

作者信息

Chen Shanjiang, Wu Shu, Lin Bin

机构信息

Department of Cardiovascular Medicine, Wenzhou Central Hospital, Wenzhou, China.

出版信息

Front Cardiovasc Med. 2024 Jul 8;11:1417672. doi: 10.3389/fcvm.2024.1417672. eCollection 2024.

DOI:10.3389/fcvm.2024.1417672
PMID:39041001
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11260750/
Abstract

Matrine (MT) and Oxymatrine (OMT) are two natural alkaloids derived from plants. These bioactive compounds are notable for their diverse pharmacological effects and have been extensively studied and recognized in the treatment of cardiovascular diseases in recent years. The cardioprotective effects of MT and OMT involve multiple aspects, primarily including antioxidative stress, anti-inflammatory actions, anti-atherosclerosis, restoration of vascular function, and inhibition of cardiac remodeling and failure. Clinical pharmacology research has identified numerous novel molecular mechanisms of OMT and MT, such as JAK/STAT, Nrf2/HO-1, PI3 K/AKT, TGF-β1/Smad, and Notch pathways, providing new evidence supporting their promising therapeutic potential against cardiovascular diseases. Thus, this review aims to investigate the potential applications of MT and OMT in treating cardiovascular diseases, encompassing their mechanisms, efficacy, and safety, confirming their promise as lead compounds in anti-cardiovascular disease drug development.

摘要

苦参碱（MT）和氧化苦参碱（OMT）是两种从植物中提取的天然生物碱。这些生物活性化合物以其多样的药理作用而闻名，近年来在心血管疾病治疗方面得到了广泛研究和认可。MT和OMT的心脏保护作用涉及多个方面，主要包括抗氧化应激、抗炎作用、抗动脉粥样硬化、恢复血管功能以及抑制心脏重塑和衰竭。临床药理学研究已经确定了OMT和MT的许多新分子机制，如JAK/STAT、Nrf2/HO-1、PI3 K/AKT、TGF-β1/Smad和Notch信号通路，为它们在心血管疾病治疗中具有广阔的治疗潜力提供了新证据。因此，本综述旨在探讨MT和OMT在治疗心血管疾病中的潜在应用，包括其作用机制、疗效和安全性，证实它们作为抗心血管疾病药物开发中先导化合物的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb08/11260750/e2fd81dd0669/fcvm-11-1417672-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb08/11260750/2d3a0728c3eb/fcvm-11-1417672-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb08/11260750/4c81271816a4/fcvm-11-1417672-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb08/11260750/30859ccb906e/fcvm-11-1417672-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb08/11260750/e2fd81dd0669/fcvm-11-1417672-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb08/11260750/2d3a0728c3eb/fcvm-11-1417672-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb08/11260750/4c81271816a4/fcvm-11-1417672-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb08/11260750/30859ccb906e/fcvm-11-1417672-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb08/11260750/e2fd81dd0669/fcvm-11-1417672-g004.jpg

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