Zhang X H, Zhang T H
Department of Ultrastructure, Nanjing Army General Hospital.
Zhonghua Nei Ke Za Zhi. 1990 Feb;29(2):105-7, 127.
Beta 2-Microglobulin expression on hepatocyte membrane was studied in 117 liver biopsies from patients with acute and chronic hepatitis B and in 11 subjects with normal liver function, using immunohistochemical PAP method. In normal liver beta 2-microglobulin could not be detected on hepatocyte membrane, compared with that in subjects with normal liver, in asymptomatic HBsAg carrier and in patients with chronic persistent hepatitis, there is significant enhancement of beta 2-microglobulin expression in patients with acute mild hepatitis and chronic mild active hepatitis. Beta 2-Microglobulin expression in patients with chronic active hepatitis with moderate to severe activity and cirrhosis has a significant enhancement, when compared with acute mild hepatitis and chronic mild active hepatitis. Moreover, location of beta 2-microglobulin expression on hepatocyte membrane was associated with lesion of hepatocytes. Enhanced expression of beta 2-microglobulin on hepatocyte membrane in acute and chronic hepatitis B probably reflects enhanced display of HLA-ABC antigens and may influence the course of hepatitis B virus infection by increasing susceptibility of T cell-mediated hepatocytelysis.
采用免疫组织化学PAP法，对117例急慢性乙型肝炎患者的肝活检组织以及11例肝功能正常者的肝组织进行研究，观察肝细胞膜上β2微球蛋白的表达情况。在正常肝脏中，肝细胞膜上无法检测到β2微球蛋白。与肝功能正常者、无症状HBsAg携带者及慢性持续性肝炎患者相比，急性轻度肝炎和慢性轻度活动性肝炎患者肝细胞膜上β2微球蛋白的表达显著增强。与急性轻度肝炎和慢性轻度活动性肝炎相比，中度至重度活动的慢性活动性肝炎及肝硬化患者β2微球蛋白的表达显著增强。此外，肝细胞膜上β2微球蛋白的表达位置与肝细胞病变有关。急慢性乙型肝炎患者肝细胞膜上β2微球蛋白表达增强，可能反映了HLA-ABC抗原的表达增加，并可能通过增加T细胞介导的肝细胞溶解易感性来影响乙型肝炎病毒感染的进程。
