Nagafuchi Y, Scheuer P J
Hepatology. 1986 Jan-Feb;6(1):20-3. doi: 10.1002/hep.1840060105.
beta 2-Microglobulin display was examined in 131 liver biopsies from patients with acute and chronic type B hepatitis, using an indirect immunoperoxidase method. Enhanced expression of beta 2-microglobulin on hepatocyte membranes was observed in patients with acute hepatitis, chronic active hepatitis with moderate to severe activity and cirrhosis, when compared with normal liver. In acute hepatitis, beta 2-microglobulin-positive hepatocytes were mainly observed in perivenular areas in association with bridging necrosis. In chronic hepatitis, beta 2-microglobulin-positive hepatocytes were observed mainly in periportal zones and in some areas of lobular activity. Diffuse-enhanced display of beta 2-microglobulin on hepatocytes was observed in 5 of 6 patients treated with lymphoblastoid interferon as part of a trial of antiviral therapy. The mechanism by which beta 2-microglobulin display is enhanced on hepatocytes in patients not treated with interferon is uncertain. However, display of beta 2-microglobulin on hepatocytes probably reflects display of HLA-A, B and C antigens and may influence the course of hepatitis B virus infection by increasing susceptibility of the affected cells to T cell-mediated immune attack.
采用间接免疫过氧化物酶法，对131例急慢性乙型肝炎患者的肝脏活检标本进行了β2微球蛋白检测。与正常肝脏相比，急性肝炎、中度至重度活动的慢性活动性肝炎和肝硬化患者的肝细胞膜上β2微球蛋白表达增强。在急性肝炎中，β2微球蛋白阳性肝细胞主要见于汇管区周围与桥接坏死相关的区域。在慢性肝炎中，β2微球蛋白阳性肝细胞主要见于汇管区周围和小叶活动的一些区域。作为抗病毒治疗试验的一部分，6例接受淋巴母细胞干扰素治疗的患者中有5例观察到肝细胞上β2微球蛋白弥漫性增强表达。未接受干扰素治疗的患者肝细胞上β2微球蛋白表达增强的机制尚不清楚。然而，肝细胞上β2微球蛋白的表达可能反映了HLA - A、B和C抗原的表达，并且可能通过增加受影响细胞对T细胞介导的免疫攻击的易感性来影响乙型肝炎病毒感染的进程。
