Nagafuchi Y, Hobbs K E, Thomas H C, Scheuer P J
Lancet. 1985 Mar 9;1(8428):551-4. doi: 10.1016/s0140-6736(85)91209-7.
The distribution of beta 2-microglobulin was studied by an immunoperoxidase method in paraffin sections from sixteen serial graft liver biopsy samples taken after liver transplantation from four patients who had received transplants for advanced primary biliary cirrhosis. Mild to moderate acute rejection was diagnosed in three of the patients. Expression of beta 2-microglobulin on hepatocyte membranes was greater during rejection, and tended to fall after the rejection episode. However, a few hepatocytes continued to display beta 2-microglobulin on their cell membranes. Rejection was characterised histologically by infiltration of portal tracts with lymphoid cells, and cholestasis. Enhanced display of beta 2-microglobulin on hepatocytes probably reflects display of HLA A, B, and C antigens and may be associated with increased susceptibility of the affected cells to T-lymphocyte-mediated immune attack.
采用免疫过氧化物酶法对4例因晚期原发性胆汁性肝硬化接受肝移植的患者的16份连续移植肝活检石蜡切片样本中β2-微球蛋白的分布进行了研究。其中3例患者被诊断为轻度至中度急性排斥反应。在排斥反应期间，肝细胞膜上β2-微球蛋白的表达增加，排斥反应发作后有下降趋势。然而，仍有一些肝细胞在其细胞膜上持续表达β2-微球蛋白。组织学上，排斥反应的特征为门管区淋巴细胞浸润和胆汁淤积。肝细胞上β2-微球蛋白的表达增强可能反映了HLA A、B和C抗原的表达，并且可能与受影响细胞对T淋巴细胞介导的免疫攻击的易感性增加有关。
