Yuan Z W
Liaoning Provinical Institute of Oceupational Health, Shenyang.
Zhonghua Yu Fang Yi Xue Za Zhi. 1990 Jul;24(4):217-9.
The left ventricular function of 26 workers exposed to fluorine was investigated. The results demonstrated that the LVET in the higher urine fluorine group (greater than 1.5 mg/L) was significantly shorter than the control group (P less than 0.01), the PEP was much longer than the control group (P less than 0.05), and the rate of PEP/LVET compared with the control group was increased. The difference was statistically significant (P less than 0.01). In the lower urine fluorine group (less than 1.5 mg/L) the time of LVET and PEP and the rate of PEP/LVET was not significantly different from the control group. The results showed that excessive fluorine ion in the body could cause decrease of myocardial contraction. The reason may be, that the fluorine ion inhibits the activities of certain enzymes in the body, thereby producing inhibition of ATP supply and utilization.
对26名接触氟的工人的左心室功能进行了调查。结果表明，高尿氟组（大于1.5mg/L）的左室射血时间（LVET）明显短于对照组（P<0.01），射血前期（PEP）明显长于对照组（P<0.05），PEP/LVET比值与对照组相比升高。差异有统计学意义（P<0.01）。低尿氟组（小于1.5mg/L）的LVET、PEP时间及PEP/LVET比值与对照组无明显差异。结果表明，体内过量氟离子可导致心肌收缩力下降。原因可能是氟离子抑制了体内某些酶的活性，从而对ATP的供应和利用产生抑制作用。
