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The benefits and risks of stem cell technology.干细胞技术的益处和风险。
Oral Dis. 2012 Apr;18(3):217-22. doi: 10.1111/j.1601-0825.2011.01870.x. Epub 2011 Nov 18.
2
About stem cell research in dentistry: many doubts and too many pitfalls still affect the regenerative dentistry.关于牙科中的干细胞研究:许多疑问和太多陷阱仍然影响着再生牙科。
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Chemical control of stem cell fate and developmental potential.化学调控干细胞命运和发育潜能。
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Stem cell-biomaterial interactions for regenerative medicine.干细胞-生物材料相互作用在再生医学中的应用。
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Stem Cells and Acellular Preparations in Bone Regeneration/Fracture Healing: Current Therapies and Future Directions.干细胞和无细胞制剂在骨再生/骨折愈合中的应用:当前治疗方法和未来方向。
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本文引用的文献

1
Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip.胚层和谱系限制的干细胞/祖细胞可使小鼠指尖再生。
Nature. 2011 Aug 24;476(7361):409-13. doi: 10.1038/nature10346.
2
Stem cells and inflammation in the intestine.肠道中的干细胞与炎症
Recent Results Cancer Res. 2011;185:51-63. doi: 10.1007/978-3-642-03503-6_3.
3
Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons.将阿尔茨海默病患者的皮肤成纤维细胞定向转化为功能性神经元。
Cell. 2011 Aug 5;146(3):359-71. doi: 10.1016/j.cell.2011.07.007.
4
Cardiomyocytes obtained from induced pluripotent stem cells with long-QT syndrome 3 recapitulate typical disease-specific features in vitro.诱导多能干细胞来源的长 QT 综合征 3 型心肌细胞在体外再现典型的疾病特异性特征。
Circ Res. 2011 Sep 30;109(8):841-7. doi: 10.1161/CIRCRESAHA.111.243139. Epub 2011 Jul 28.
5
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations.生成仅在两个早发性帕金森病点突变处存在差异的同基因多能干细胞。
Cell. 2011 Jul 22;146(2):318-31. doi: 10.1016/j.cell.2011.06.019. Epub 2011 Jul 14.
6
Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs.靶向纠正患者特异性 iPSC 中与层粘连蛋白病相关的 LMNA 突变。
Cell Stem Cell. 2011 Jun 3;8(6):688-94. doi: 10.1016/j.stem.2011.04.019. Epub 2011 May 19.
7
Modelling long QT syndrome with iPS cells: be still, my beating heart ..利用诱导多能干细胞模拟长QT综合征:安静下来,我的跳动之心……
Circ Res. 2011 Mar 18;108(6):648-9. doi: 10.1161/RES.0b013e318216f0db.
8
Stem and progenitor cells for neurological repair: minor issues, major hurdles, and exciting opportunities for paracrine-based therapeutics.神经修复用干细胞和祖细胞:旁分泌治疗的次要问题、主要障碍和令人兴奋的机会。
J Cell Biochem. 2011 Feb;112(2):374-80. doi: 10.1002/jcb.22963.
9
Stem cell-based biological tooth repair and regeneration.基于干细胞的生物性牙齿修复与再生。
Trends Cell Biol. 2010 Dec;20(12):715-22. doi: 10.1016/j.tcb.2010.09.012. Epub 2010 Oct 28.
10
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.通过定义因子将成纤维细胞直接重编程为功能性心肌细胞。
Cell. 2010 Aug 6;142(3):375-86. doi: 10.1016/j.cell.2010.07.002.

干细胞技术的益处和风险。

The benefits and risks of stem cell technology.

机构信息

Center for Molecular Medicine,National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10-CRC, Room 5-3132, Bethesda, MD 20817, USA.

出版信息

Oral Dis. 2012 Apr;18(3):217-22. doi: 10.1111/j.1601-0825.2011.01870.x. Epub 2011 Nov 18.

DOI:10.1111/j.1601-0825.2011.01870.x
PMID:22093062
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3752464/
Abstract

The potential impact of stem cell technology on medical and dental practice is vast. Stem cell research will not only provide the foundation for future therapies, but also reveal unique insights into basic disease mechanisms. Therefore, an understanding of stem cell technology will be necessary for clinicians in the future. Herein, we give a basic overview of stem cell biology and therapeutics for the practicing clinician.

摘要

干细胞技术对医学和牙科实践的潜在影响是巨大的。干细胞研究不仅将为未来的治疗提供基础,还将揭示基本疾病机制的独特见解。因此,未来的临床医生需要了解干细胞技术。本文为临床医生提供了干细胞生物学和治疗学的基本概述。