Salehi-Pourmehr Hanieh, Hajebrahimi Sakineh, Rahbarghazi Reza, Pashazadeh Fariba, Mahmoudi Javad, Maasoumi Narjes, Sadigh-Eteghad Saeed
Research Center for Evidence-Based Medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
Urology Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Int Neurourol J. 2020 Sep;24(3):241-257. doi: 10.5213/inj.2040058.029. Epub 2020 Sep 30.
Neurogenic bladder dysfunction (NGB) has an impact on the quality of life, which made it an important research subject in preclinical studies. The present review investigates the effect of stem cell (SC) therapy on bladder functional recovery after the onset of spinal cord injury (SCI), multiple sclerosis (MS), Parkinson disease (PD), and stroke in rodent models.
All experiments evaluated the regenerative potential of SC on the management of NGB in rodent models up to June 2019, were included. From 1,189 relevant publications, 20 studies met our inclusion criteria of which 15 were conducted on SCI, 2 on PD, 2 on stroke, and 1 on MS in the rodent models. We conducted a meta-analysis on SCI experiments and for other neurological diseases, detailed urodynamic findings were reported.
The common SC sources used for therapeutical purposes were neural progenitor cells, bone marrow mesenchymal SCs, human amniotic fluid SCs, and human umbilical cord blood SCs. There was a significant improvement of micturition pressure in both contusion and transaction SCI models 4 and 8 weeks post-SC transplantation. Residual urine volume, micturition volume, and bladder capacity were improved 28 days after SC transplantation only in the transaction model of SCI. Nonvoiding contraction recovered only in 56 days post-cell transplantation in the contusion model.
Partial bladder recovery has been evident after SC therapy in SCI models. Due to limitations in the number of studies in other neurological diseases, additional studies are necessary to confirm the detailed mechanism for bladder recovery.
神经源性膀胱功能障碍（NGB）会影响生活质量，这使其成为临床前研究中的一个重要课题。本综述研究了干细胞（SC）疗法对啮齿动物模型中脊髓损伤（SCI）、多发性硬化症（MS）、帕金森病（PD）和中风发病后膀胱功能恢复的影响。
纳入了截至2019年6月所有评估SC对啮齿动物模型中NGB管理的再生潜力的实验。从1189篇相关出版物中，有20项研究符合我们的纳入标准，其中15项在啮齿动物模型中的SCI上进行，2项在PD上进行，2项在中风上进行，1项在MS上进行。我们对SCI实验进行了荟萃分析，并报告了其他神经疾病的详细尿动力学研究结果。
用于治疗目的的常见SC来源是神经祖细胞、骨髓间充质干细胞、人羊水干细胞和人脐带血干细胞。在SC移植后4周和8周，挫伤和横断SCI模型中的排尿压力均有显著改善。仅在SCI的横断模型中，SC移植后28天残余尿量、排尿量和膀胱容量得到改善。在挫伤模型中，非排尿收缩仅在细胞移植后56天恢复。
在SCI模型中，SC治疗后膀胱部分恢复明显。由于其他神经疾病的研究数量有限，需要更多研究来证实膀胱恢复的详细机制。
