大鼠干扰素。VI. 异源干扰素在病毒感染治疗中的应用。

Rat interferons. VI. Heterologous interferon in the treatment of viral infections.

作者信息

Lobodzińska M, Albin M

出版信息

Arch Immunol Ther Exp (Warsz). 1979;27(1-2):247-52.

Abstract

In previous studies in vitro we demonstrated the protection of mouse cells against viral infections by rat interferon. In continuation, the present paper reports results of a study designed to confirm this heterospecific activity of rat interferon in vivo. Experiments were carried out with mice of the inbred 129/AoBoy strain, inoculated intranasally or intraperitoneally with EMC-strain Col MM, VSV and influenza A 055/74 viruses, and treated with mouse or rat interferon administered by the same routes as infection. Both interferons exhibited protective action. The therapeutic effect of the mouse and rat interferons was dependent on the infecting dose of the viruses. Rat interferon proved more effective in the treatment of mice infected intraperitoneally than mice infected intranasally.

摘要

在之前的体外研究中，我们证明了大鼠干扰素对小鼠细胞具有抗病毒感染的保护作用。作为后续研究，本文报告了一项旨在证实大鼠干扰素在体内这种异源特异性活性的研究结果。实验使用的是近交129/AoBoy品系小鼠，通过鼻内或腹腔内接种EMC株Col MM、VSV和甲型流感病毒055/74，并以与感染相同的途径给予小鼠或大鼠干扰素进行治疗。两种干扰素均表现出保护作用。小鼠和大鼠干扰素的治疗效果取决于病毒的感染剂量。事实证明，大鼠干扰素对腹腔内感染的小鼠的治疗效果比对鼻内感染的小鼠更有效。

相似文献

1

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2

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