五钨二锑酸铵对小鼠脑心肌炎病毒和水疱性口炎病毒感染的影响。

Effect of ammonium 5-tungsto-2-antimoniate on encephalomyocarditis and vesicular stomatitis virus infections in mice.

作者信息

Werner G H, Jasmin C, Chermann J C

出版信息

J Gen Virol. 1976 Apr;31(1):59-64. doi: 10.1099/0022-1317-31-1-59.

Abstract

Ammonium 5-tungsto-2-antimoniate (HPA 23) protected micr partially or completely against two strains of encephalomyocarditis (EMC) virus and one strain of vesicular stomatitis (VSV) virus. The best protective effect was obtained with EMC strain VR 129 and VSV when a single i.p. injection of HPA 23 was administered shortly before virus inoculation. Mice protected by HPA 23 against EMC strain VR129 had virus titres in the blood and brain similar to those in untreated mice. A synergism between interferon and HPA 23 was observed in mice infected with EMC VR129. Our results demonstrate the in vivo activity of HPA 23 against two lethal viral infections and suggest that, at least in mice infected with EMC, death may not be related solely to virus multiplication.

摘要

5-钨-2-锑酸铵（HPA 23）对两株脑心肌炎（EMC）病毒和一株水泡性口炎（VSV）病毒具有部分或完全的保护作用。在病毒接种前不久经腹腔单次注射HPA 23时，对EMC毒株VR 129和VSV可获得最佳保护效果。受HPA 23保护的小鼠在抵抗EMC毒株VR129时，其血液和大脑中的病毒滴度与未处理小鼠相似。在感染EMC VR129的小鼠中观察到干扰素与HPA 23之间存在协同作用。我们的结果证明了HPA 23对两种致死性病毒感染的体内活性，并表明，至少在感染EMC的小鼠中，死亡可能不仅仅与病毒增殖有关。