Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, Taiwan, ROC.
Prog Mol Biol Transl Sci. 2011;104:101-40. doi: 10.1016/B978-0-12-416020-0.00003-6.
Dendrimers consisting of inner core and peripheral shell are well-designed branching architectures with abundant terminal groups. Therefore, the high level of control over dendritic architectures makes dendrimers ideal carriers in biomedical application. In addition, the toxicity of dendrimers mainly comes from the high cationic charge density in the periphery, where charges interact with biological cell membrane and then result in membrane disruption. Two strategies have been utilized to minimize the toxicity of dendrimers: first, selecting neutral or anionic biocompatible dendrimers, and second, masking of peripheral charge by chemical modification. Then the focus of this chapter shifts to biomedical application of biocompatible dendrimers, including drug delivery systems of dendrimers, targeting delivery by dendrimers, and applications of dendrimers for therapy and as imaging agents for inspection.
树状聚合物由核和外壳组成，是具有丰富末端基团的精心设计的分支结构。因此，对树状聚合物结构的高度控制使其成为生物医学应用中的理想载体。此外，树状聚合物的毒性主要来自于外围的高阳离子电荷密度，其中电荷与生物细胞膜相互作用，然后导致膜破裂。有两种策略可用于最大程度地降低树状聚合物的毒性：首先，选择中性或阴离子型生物相容性树状聚合物，其次，通过化学修饰掩蔽外围电荷。然后，本章的重点转向生物相容的树状聚合物在生物医学中的应用，包括树状聚合物的药物传递系统、树状聚合物的靶向传递以及树状聚合物在治疗中的应用和作为成像剂用于检查。
