Department of Dermatology, University of Texas at Houston, Houston, Texas, USA.
Dermatol Surg. 2012 Feb;38(2):199-206. doi: 10.1111/j.1524-4725.2011.02178.x. Epub 2011 Oct 10.
A 1,927-nm wavelength was recently added to the 1,550-nm erbium-doped fiber laser. This wavelength possesses a higher absorption coefficient for water than the 1,550-nm, conferring greater ability to target epidermal processes such as dyschromia.
To evaluate the efficacy and safety of a novel 1,927-nm fractional thulium fiber laser in the treatment of melasma.
Fourteen patients underwent three to four laser treatments (at 4-week intervals) at pulse energies of 10 to 20 mJ and total densities of 252 to 784 microscopic treatment zones per cm(2) (6-8 passes) using a 1,927-nm thulium fiber laser. Three blinded assessors and the patients evaluated clinical improvement of treatment areas at 1-, 3-, and 6-month follow-ups. Side effects were assessed, and pain was scored using a visual analog scale (0-10).
A statistically significant 51% reduction in MASI score was observed at 1-month post 3 to 4 laser treatments. A 33% (p = .06) and 34% (p = .07) reduction in Melasma Area and Severity Index score was observed at the 3- and 6-month follow-up visits, respectively. Skin responses observed after treatment were moderate erythema and mild edema. No scarring or postinflammatory hyper- or hypopigmentation was observed.
The 1,927-nm fractional thulium fiber laser is a safe, effective treatment for melasma.
最近在 1550nm 掺铒光纤激光中加入了 1927nm 波长。该波长对水的吸收率比 1550nm 高，因此能够更好地靶向表皮过程，如色素沉着异常。
评估新型 1927nm 分数铥光纤激光治疗黄褐斑的疗效和安全性。
14 例患者接受了 3 至 4 次激光治疗（每 4 周一次），使用 1927nm 铥光纤激光，脉冲能量为 10 至 20mJ，总密度为 252 至 784 个微观治疗区/cm²（6-8 次）。三位盲评者和患者在 1、3 和 6 个月随访时评估治疗区域的临床改善情况。评估了不良反应，并使用视觉模拟量表（0-10）对疼痛进行评分。
3 至 4 次激光治疗后 1 个月，MASI 评分显著降低 51%。在 3 个月和 6 个月的随访中，MASI 评分分别降低了 33%（p=0.06）和 34%（p=0.07）。治疗后观察到的皮肤反应为中度红斑和轻度水肿。未观察到瘢痕或炎症后色素过度或减退。
1927nm 分数铥光纤激光是治疗黄褐斑的一种安全、有效的方法。
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