Department of Nosocomial Infection Management and Disease Control, Institute of Hospital Management, Chinese People's Liberation Army General Hospital, Beijing, China.
Int J Gynaecol Obstet. 2012 Feb;116(2):148-52. doi: 10.1016/j.ijgo.2011.08.024. Epub 2011 Nov 16.
To investigate the pregnancy complications, perinatal outcomes, and congenital abnormalities (CAs) that occurred in Beijing, China, when pregnant women became infected with the 2009 pandemic influenza A (H1N1) (H1N1 pdm).
Pregnancy complications, perinatal outcomes, and CAs were compared among 3 groups of pregnant women. The 23 women in group 1 were confirmed to harbor viral RNA; the 23 in group 2 had serum levels of virus-specific antibodies against H1N1 pdm, meaning that they were suspected of being infected with the virus; and the 93 in group 3 had no detectable virus-specific antibodies.
Perinatal outcomes and pregnancy complications were not significantly different in groups 1 and 3. Higher percentages of stillbirths (12.0%) and placental disorders (13.0%) were observed in group 2 than in group 3. Many women in group 2 (62.5%) experienced symptoms of having a cold during pregnancy and most took no medication. Two cases of CA occurred in group 1, in the offspring of women infected in the second trimester.
When left untreated, infection with the 2009 H1N1 pdm virus during pregnancy appears to have increased fetal mortality and morbidity. Because CAs are traumatic for all concerned, their possible association with the virus should be further evaluated.
调查中国北京地区孕妇感染 2009 年甲型 H1N1 流感（H1N1 pdm）后发生的妊娠并发症、围产儿结局和先天性异常（CA）。
比较了 3 组孕妇的妊娠并发症、围产儿结局和 CA。组 1 的 23 名孕妇病毒 RNA 检测阳性；组 2 的 23 名孕妇血清中存在针对 H1N1 pdm 的病毒特异性抗体，提示疑似感染病毒；组 3 的 93 名孕妇未检测到病毒特异性抗体。
组 1 和组 3 的围产儿结局和妊娠并发症无显著差异。组 2 的死胎率（12.0%）和胎盘异常率（13.0%）高于组 3。组 2 中有许多孕妇（62.5%）在妊娠期间出现感冒症状，且大多数未服用药物。组 1 中有 2 例 CA，发生在孕妇妊娠中期感染的胎儿中。
孕妇感染 2009 年 H1N1 pdm 病毒后，如果不进行治疗，似乎会增加胎儿死亡率和发病率。由于 CA 对所有相关人员都是创伤性的，应进一步评估其与病毒的可能关联。
