Zheng X, Huang Y, Wang Z, Yan H, Pan S, Wang H
Department of Hematology, The General Hospital of Air Force P.L.A., Beijing, China.
Transpl Infect Dis. 2012 Apr;14(2):177-9. doi: 10.1111/j.1399-3062.2011.00678.x. Epub 2011 Sep 28.
A case of cytomegalovirus (CMV)-associated bilateral retrobulbar optic neuritis (ON) following haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is reported. Abrupt onset of bilateral decreased vision occurred in a 33-year-old man 7 months after haplo-HSCT. His cerebrospinal fluid (CSF) demonstrated pleocytosis with an absence of leukemic cells. CMV DNA was detected in his blood and CSF sample. Neither encephalopathy nor retinopathy was found in this patient. He was diagnosed with bilateral retrobulbar ON. Although he was given enough antiviral treatment against CMV and immunosuppression with high-dose methylprednisolone, the patient's vision showed no improvement, and he has almost total bilateral blindness. This is the first report, to our knowledge, of CMV-associated bilateral retrobulbar ON in allogeneic stem cell transplantation.
报告了1例单倍体造血干细胞移植（haplo-HSCT）后发生巨细胞病毒（CMV）相关双侧球后视神经炎（ON）的病例。一名33岁男性在haplo-HSCT后7个月突然出现双侧视力下降。他的脑脊液（CSF）显示细胞增多，无白血病细胞。在他的血液和脑脊液样本中检测到CMV DNA。该患者未发现脑病或视网膜病变。他被诊断为双侧球后视神经炎。尽管给予了足够的抗CMV抗病毒治疗和大剂量甲基强的松龙免疫抑制治疗，但患者的视力没有改善，几乎完全双侧失明。据我们所知，这是首例关于异基因干细胞移植中CMV相关双侧球后视神经炎的报告。
