Lu Xiang-Cheng, Zhou Yong-Gang, Wang Yan
Department of Orthopedic Surgery, General Hospital of Chinese PLA, Beijing 100853, China.
Zhonghua Yi Xue Za Zhi. 2011 Jul 5;91(25):1762-5.
To review the type and number of pathogens and their antibiotic sensitivity in patients with late infected total joint replacement so as to offer guidance for the choice of antibiotics.
A retrospective analysis was conducted for 62 patients whose suspected specimens were obtained intra-operatively during a total hip arthroplasty since January 2002 to August 2010 at our department. Their demographic data, bacterial species and antibiotic sensitivity profiles were recorded.
Among 62 cases, the cultures were tested positive in 48 cases; the most common bacteria was Gram-positive bacteria (74%). And coagulase-negative staphylococci and Staphylococcus aureus accounted for 62.9% of all bacterial cultures. And the ratio of methicillin-resistant Staphylococcus was 41.18%.
The late infection of total hip arthroplasty is mainly caused by Gram-positive bacteria. Antibiotic treatment for late periprosthetic infection should be guided by the findings of drug susceptibility. Vancomycin may be used as a primary agent for the treatment of infected hip arthroplasty.
回顾晚期感染性全关节置换患者的病原体类型、数量及其抗生素敏感性，为抗生素的选择提供指导。
对2002年1月至2010年8月在我科行全髋关节置换术期间术中获取疑似标本的62例患者进行回顾性分析。记录其人口统计学数据、细菌种类及抗生素敏感性谱。
62例中，48例培养阳性；最常见的细菌为革兰氏阳性菌（74%）。凝固酶阴性葡萄球菌和金黄色葡萄球菌占所有细菌培养的62.9%。耐甲氧西林葡萄球菌的比例为41.18%。
全髋关节置换术后晚期感染主要由革兰氏阳性菌引起。假体周围晚期感染的抗生素治疗应以药敏结果为指导。万古霉素可作为治疗感染性髋关节置换术的首选药物。
