Deibert Peter, Lutz Lisa, Konig Daniel, Zitta Sabine, Meinitzer Andreas, Vitolins Mara Z, Becker Gerhild, Berg Aloys
University hospital, Department of Rehabilitative and Preventive Sports Medicine, Freiburg, Germany.
Asia Pac J Clin Nutr. 2011;20(4):527-34.
Soy protein is used for meal replacement therapy in obesity, however the influence on renal function parameters is not adequately investigated. This study evaluates glomerular filtration rate (GFR) and renal plasma flow (RPF) in patients with the metabolic syndrome and healthy controls after ingestion of different amounts of soy protein.
10 patients with the metabolic syndrome but no signs of kidney disease and 10 healthy controls ingested 1 g protein/kg body weight of a commercial soy-yoghurt-honeypreparation. The patient group was also given a protein challenge of 0.3 g/kg body weight.
Baseline GFR and RPF both were significantly higher in the patient group (147 ± 34.8 vs. 116 ± 21.1 ml/min, p=0.01 and 848 ± 217 vs. 637 ± 121 ml/min, p=0.02) and were strongly correlated with body weight. Use of different algorithms to estimate GFR resulted in underestimation of GFR, particularly in the patients with the metabolic syndrome. The challenge with an acute protein load of 1g protein per kilogram body weight induced a significant increase in GFR and RPF in healthy controls (GFR: +12.6 ± 11.0 % (p=0.01), RPF: +13.6 ± 15.6 % (p=0.04)) and even more in patients with the metabolic syndrome (GFR: +31.5 ± 32.2 % (p=0.01); RPF: +19.4 ± 22.7 % (p=0.02)). The ingestion of 0.3 g protein/ kg body weight did not induce significant changes.
Basic renal function is changed in patients with the metabolic syndrome, even without microalbuminuria. In addition, there is an elevated susceptibility for protein load. However, the protein amount recommended for use in soy-protein based meal replacement therapy induced no significant changes.
大豆蛋白用于肥胖症的代餐疗法，然而其对肾功能参数的影响尚未得到充分研究。本研究评估了代谢综合征患者和健康对照者在摄入不同量大豆蛋白后肾小球滤过率（GFR）和肾血浆流量（RPF）的变化。
10例患有代谢综合征但无肾脏疾病迹象的患者和10名健康对照者摄入了每千克体重1克蛋白质的市售大豆酸奶蜂蜜制剂。患者组还接受了每千克体重0.3克蛋白质的蛋白质激发试验。
患者组的基线GFR和RPF均显著更高（分别为147±34.8对116±21.1毫升/分钟，p = 0.01；848±217对637±121毫升/分钟，p = 0.02），且与体重密切相关。使用不同算法估算GFR会导致GFR被低估，尤其是在代谢综合征患者中。每千克体重1克蛋白质的急性蛋白质负荷激发试验使健康对照者的GFR和RPF显著增加（GFR：+12.6±11.0%（p = 0.01），RPF：+13.6±15.6%（p = 0.04）），在代谢综合征患者中增加更为明显（GFR：+31.5±32.2%（p = 0.01）；RPF：+19.4±22.7%（p = 0.02））。每千克体重摄入0.3克蛋白质未引起显著变化。
即使没有微量白蛋白尿，代谢综合征患者的基础肾功能也会发生改变。此外，对蛋白质负荷的敏感性增加。然而，基于大豆蛋白的代餐疗法推荐使用的蛋白质量并未引起显著变化。
