Rafieian-Kopaei Mahmoud, Beigrezaei Sara, Nasri Hamid, Kafeshani Marzieh
Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Department of Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Prev Med. 2017 Dec 13;8:105. doi: 10.4103/ijpvm.IJPVM_244_17. eCollection 2017.
Chronic kidney disease (CKD) is a serious universal problem that is the main risk for several diseases including cardiovascular disease. Dietary factors are important to prevent and control the kidney disease. Some evidence has shown that modifying the amount and the types of dietary protein exert a major effect on renal failure so limiting dietary protein and substituting animal protein with soy protein has suggested. However, there is a lot of controversy about it, especially in human. Thus, this paper will review the clinical trial studies conducted on the effects of soy protein intake on CKD in both animal and human and its effect mechanism.
慢性肾脏病（CKD）是一个严重的全球性问题，是包括心血管疾病在内的多种疾病的主要风险因素。饮食因素对于预防和控制肾脏疾病很重要。一些证据表明，调整饮食蛋白质的量和类型对肾衰竭有重大影响，因此建议限制饮食蛋白质并将动物蛋白替换为大豆蛋白。然而，对此存在很多争议，尤其是在人体研究方面。因此，本文将综述关于大豆蛋白摄入对动物和人体慢性肾脏病影响的临床试验研究及其作用机制。
