Centre for Nanotechnology and Regenerative Medicine, UCL Division of Surgery and Interventional Sciences, University College London, London, UK.
J Tissue Eng Regen Med. 2012 Nov;6(10):757-68. doi: 10.1002/term.487. Epub 2011 Nov 17.
Cartilage tissue engineering is a rapidly progressing area of regenerative medicine with advances in cell biology and scaffold engineering constantly being investigated. Many groups are now capable of making neocartilage constructs with some level of morphological, biochemical, and histological likeness to native human cartilage tissues. The application of this useful technology in articular cartilage repair is well described in the literature; however, few studies have evaluated its application in head and neck reconstruction. Although there are many studies on auricular cartilage tissue engineering, there are few studies regarding cartilage tissue engineering for complex nasal reconstruction. This study therefore highlighted the challenges involved with nasal reconstruction, with special focus on nasal cartilage tissue, and examined how advancements made in cartilage tissue engineering research could be applied to improve the clinical outcomes of total nasal reconstructive surgery.
软骨组织工程是再生医学中一个快速发展的领域，细胞生物学和支架工程的进展不断得到研究。许多研究小组现在已经能够制造出具有一定形态、生化和组织学相似性的新软骨构建体，类似于天然的人类软骨组织。该有用技术在关节软骨修复中的应用在文献中已有很好的描述；然而，很少有研究评估其在头颈部重建中的应用。尽管有许多关于耳廓软骨组织工程的研究，但关于复杂鼻重建的软骨组织工程研究很少。因此，本研究强调了鼻重建所涉及的挑战，特别关注鼻软骨组织，并探讨了如何应用软骨组织工程研究的进展来改善全鼻重建手术的临床结果。
