MicroNano System Research Center, College of Information and Computer, Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education, Taiyuan University of Technology, Taiyuan, 030024, China.
College of Information Science and Engineering, Hebei North University, Zhangjiakou, 075000, China.
Aesthetic Plast Surg. 2022 Apr;46(2):947-964. doi: 10.1007/s00266-021-02472-4. Epub 2021 Jul 26.
Once cartilage is damaged, its self-repair capacity is very limited. The strategy of tissue engineering has brought a new idea for repairing cartilage defect and cartilage regeneration. In particular, nasal cartilage regeneration is a challenge because of the steady increase in nasal reconstruction after oncologic resection, trauma, or rhinoplasty. From this perspective, three-dimensional (3D) printing has emerged as a promising technology to address the complexity of nasal cartilage regeneration, using patient's image data and computer-aided deposition of cells and biomaterials to precisely fabricate complex, personalized tissue-engineered constructs. In this review, we summarized the major progress of three prevalent 3D printing approaches, including inkjet-based printing, extrusion-based printing and laser-assisted printing. Examples are highlighted to illustrate 3D printing for nasal cartilage regeneration, with special focus on the selection of seeded cell, scaffolds and growth factors. The purpose of this paper is to systematically review recent research about the challenges and progress and look forward to the future of 3D printing techniques for nasal cartilage regeneration.Level of Evidence III This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors https://www.springer.com/00266 .
一旦软骨受损,其自我修复能力非常有限。组织工程学策略为修复软骨缺损和软骨再生带来了新的思路。特别是,由于肿瘤切除、外伤或鼻整形术后鼻重建的需求不断增加,鼻软骨再生是一个挑战。从这个角度来看,三维(3D)打印技术的出现为解决鼻软骨再生的复杂性带来了希望,它利用患者的图像数据和计算机辅助细胞和生物材料的沉积,精确地制造复杂的、个性化的组织工程结构。在这篇综述中,我们总结了三种流行的 3D 打印方法的主要进展,包括喷墨打印、挤出打印和激光辅助打印。举例说明了 3D 打印在鼻软骨再生中的应用,特别关注种子细胞、支架和生长因子的选择。本文的目的是系统地回顾鼻软骨再生的 3D 打印技术的挑战和进展,并展望其未来。
证据水平 III 本刊要求作者对每个适用循证医学分级的投稿指定一个证据水平。这排除了综述文章、书评和涉及基础科学、动物研究、尸体研究和实验研究的手稿。有关这些循证医学评级的完整描述,请参阅目录或在线投稿说明 https://www.springer.com/00266 。