Wiggenhauser Paul Severin, Schantz Jan Thorsten, Rotter Nicole
sup>Department of Oto-Rhino-Laryngology, Head & Neck Surgery, Ulm University Medical Center, Frauensteige 12, Ulm DE 89075, Germany.
Department of Hand, Plastic & Aesthetic Surgery, Ludwig Maximilian University of Munich, Pettenkoferstrasse 8a, Munich DE 80336, Germany.
Regen Med. 2017 Apr;12(3):303-314. doi: 10.2217/rme-2016-0160. Epub 2017 May 19.
This review provides an update on cartilage tissue engineering with particular focus on the head and neck. It is aimed at scientists and clinicians who are interested in tissue engineering and its clinical applicability. Principal tissue engineering strategies are summarized in the first part of this review. In the second part, current clinical approaches to auricular, nasal and tracheal reconstruction are discussed from a surgical perspective. By this approach, the requirements for clinical applicability are outlined and new insight into relevant aims of research is given to accelerate the transfer from bench to bedside.
本综述提供了软骨组织工程的最新进展，特别关注头颈部。它面向对组织工程及其临床应用感兴趣的科学家和临床医生。本综述的第一部分总结了主要的组织工程策略。在第二部分中，从外科角度讨论了目前耳廓、鼻和气管重建的临床方法。通过这种方式，概述了临床应用的要求，并对相关研究目标提供了新的见解，以加速从实验室到临床的转化。
