Department of Fibre and Polymer Technology, School of Chemical Science and Engineering, KTH Royal Institute of Technology, Stockholm, Sweden.
Macromol Biosci. 2012 Feb;12(2):260-8. doi: 10.1002/mabi.201100288. Epub 2011 Nov 17.
The pre-polymer poly(but-2-ene-1,4-diyl malonate) (PBM) and a series of PBM-based materials are shown to be degradable under physiological conditions in vitro and they are therefore presented as potential materials for biomedical applications. Four different PBM-based materials are synthesized: a PBM homopolymer, crosslinked PBM with and without spacer, and a triblock copolymer of PBM and PLLA with the PBM as an amorphous middle block. The polymers are subjected to hydrolytic degradation in phosphate-buffered saline at pH = 7.4 and 37 °C. The results show that all the PBM-based materials degrade without a rapid release of acidic degradation products or any substantial lowering of the pH that might jeopardize their biocompatibility.
预聚物聚（丁-2-烯-1,4-二基丙二酸酯）（PBM）和一系列基于 PBM 的材料在体外生理条件下可降解，因此被认为是潜在的生物医学应用材料。合成了四种不同的基于 PBM 的材料：PBM 均聚物、交联 PBM 带和不带间隔物，以及 PBM 和 PLLA 的三嵌段共聚物，其中 PBM 为无定形中间嵌段。聚合物在 pH = 7.4 和 37°C 的磷酸盐缓冲盐水中进行水解降解。结果表明，所有基于 PBM 的材料在降解过程中不会迅速释放酸性降解产物，也不会显著降低 pH 值，从而危及它们的生物相容性。
