Deepe G S, Bullock W E
Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio 45267.
Eur J Clin Microbiol Infect Dis. 1990 Aug;9(8):567-79. doi: 10.1007/BF01967211.
The incidence of infection with the pathogenic fungi continues to escalate, especially in the era of the acquired immune deficiency syndrome. To the clinician, this heterogeneous group of organisms poses both a diagnostic and a therapeutic challenge. Consequently, growing numbers of investigators are seeking to elucidate the pathogenetic mechanisms involved in disease caused by medically important fungi. In this review, many of the recent scientific advances that have been made in the immunological aspects of the pathogenesis of fungal infections are presented. The topics covered include 1) the receptors for fungi on the surface of professional phagocytes; 2) the mechanisms for killing and growth inhibition of fungi by phagocytes; 3) the means by which fungi evade host defenses; 4) the role of humoral immunity in fungal infection; 5) immunoregulation in fungal infections; and 6) the influence of cytokines on host defenses against pathogenic fungi.
致病性真菌的感染发生率持续上升，尤其是在获得性免疫缺陷综合征时代。对于临床医生而言，这类异质性生物体在诊断和治疗方面均构成挑战。因此，越来越多的研究人员试图阐明医学上重要真菌所致疾病的发病机制。在本综述中，介绍了真菌感染发病机制免疫学方面取得的许多最新科学进展。涵盖的主题包括：1）专职吞噬细胞表面的真菌受体；2）吞噬细胞杀灭和抑制真菌生长的机制；3）真菌逃避宿主防御的方式；4）体液免疫在真菌感染中的作用；5）真菌感染中的免疫调节；6）细胞因子对宿主抵御致病性真菌的影响。
