新型碳青霉烯类药物LJC10,627的体外抗菌活性及β-内酰胺酶稳定性

In vitro antibacterial activity and beta-lactamase stability of the new carbapenem LJC10,627.

作者信息

Yoshida M, Mitsuhashi S

机构信息

Episome Institute, Gunma, Japan.

出版信息

Eur J Clin Microbiol Infect Dis. 1990 Aug;9(8):625-9. doi: 10.1007/BF01967222.

DOI:10.1007/BF01967222

PMID:2209630

Abstract

In in vitro susceptibility tests the new carbapenem LJC10,627 showed potent antibacterial activity against gram-positive and gram-negative bacteria, except that most methicillin-resistant Staphylococcus aureus strains tested were found to be resistant to LJC10,627. LJC10,627 showed high activity against Pseudomonas aeruginosa and was active against Enterobacter cloacae and Citrobacter freundii strains which were resistant to ceftazidime and cefpirome. The Ki values of LJC10,627 for penicillinase Type I, cephalosporinase and oxyiminocephalosporinase were low, whereas the Ki value for L-1 enzyme from Xanthomonas maltophilia was high.

摘要

在体外药敏试验中，新型碳青霉烯类药物LJC10,627对革兰氏阳性菌和革兰氏阴性菌均显示出强大的抗菌活性，但所检测的大多数耐甲氧西林金黄色葡萄球菌菌株对LJC10,627耐药。LJC10,627对铜绿假单胞菌显示出高活性，对耐头孢他啶和头孢匹罗的阴沟肠杆菌和弗氏柠檬酸杆菌菌株也有活性。LJC10,627对I型青霉素酶、头孢菌素酶和氧亚氨基头孢菌素酶的Ki值较低，而对嗜麦芽窄食单胞菌的L-1酶的Ki值较高。