Matsuda K, Sasaki K, Inoue K, Kondo H, Inoue M, Mitsuhashi S
Antimicrob Agents Chemother. 1985 Nov;28(5):684-8. doi: 10.1128/AAC.28.5.684.
The in vitro antibacterial activity of Sch 34343 against 1,328 strains of clinical isolates was compared with those of imipenem and ceftazidime. Sch 34343 had a broad spectrum of antibacterial activity against both gram-positive and gram-negative bacteria but was inactive against Pseudomonas aeruginosa and Pseudomonas maltophilia. Sch 34343 was quite stable to hydrolysis by beta-lactamases, including both penicillinases and cephalosporinases. However, Sch 34343 was slightly hydrolyzed by a new type of beta-lactamase (oxyiminocephalosporin beta-lactamase), as was imipenem. Sch 34343 was slightly hydrolyzed by renal dehydropeptidase 1 but was somewhat more stable than other carbapenems.
将Sch 34343对1328株临床分离菌株的体外抗菌活性与亚胺培南和头孢他啶进行了比较。Sch 34343对革兰氏阳性菌和革兰氏阴性菌均具有广谱抗菌活性，但对铜绿假单胞菌和嗜麦芽窄食单胞菌无活性。Sch 34343对包括青霉素酶和头孢菌素酶在内的β-内酰胺酶的水解作用相当稳定。然而，Sch 34343与亚胺培南一样，会被一种新型β-内酰胺酶（氧亚氨基头孢菌素β-内酰胺酶）轻微水解。Sch 34343会被肾脱氢肽酶1轻微水解，但比其他碳青霉烯类药物稍稳定一些。
