Machka K, Braveny I
Eur J Clin Microbiol. 1983 Aug;2(4):345-9. doi: 10.1007/BF02019465.
HR 810, 3-[(2,3-cyclopenteno-1-pyridinium)methyl]-7-[2-syn-methoximino-2-(2-aminothiazole-4-yl)-acetamido] ceph-3-em-4-carboxylate, is a new semisynthetic cephalosporin derivative. The in vitro activity of HR 810 was compared with that of cefotaxime, ceftazidime, piperacillin and gentamicin using 368 strains of gram-negative and gram-positive bacteria. HR 810 was highly active against Enterobacteriaceae, being the most active of the cephalosporins against Enterobacter, Serratia and Citrobacter spp.; the MICs ranged from much less than 0.06 to 8 mg/l. The activity of HR 810 against Pseudomonas aeruginosa and Acinetobacter spp. was almost as good as that of ceftazidime. The new compound was superior to the other cephalosporins against Staphylococcus aureus and inhibited all Streptococcus faecalis strains at a concentration of 16 mg/l.
HR 810，即3-[(2,3-环戊烯基-1-吡啶鎓)甲基]-7-[2-顺式甲氧基亚氨基-2-(2-氨基噻唑-4-基)-乙酰胺基]头孢-3-烯-4-羧酸酯，是一种新型半合成头孢菌素衍生物。使用368株革兰氏阴性菌和革兰氏阳性菌，将HR 810的体外活性与头孢噻肟、头孢他啶、哌拉西林和庆大霉素进行了比较。HR 810对肠杆菌科细菌具有高度活性，是对肠杆菌、沙雷氏菌和柠檬酸杆菌属最具活性的头孢菌素；最低抑菌浓度范围从远低于0.06至8mg/l。HR 810对铜绿假单胞菌和不动杆菌属的活性几乎与头孢他啶相同。该新化合物对金黄色葡萄球菌的活性优于其他头孢菌素，并在浓度为16mg/l时抑制所有粪肠球菌菌株。
