Chahar Maheep K, Sharma Neelu, Dobhal Mahabeer P, Joshi Yogesh C
Department of Chemistry, University of Rajasthan, Jaipur-302004, Rajasthan, India.
Pharmacogn Rev. 2011 Jan;5(9):1-12. doi: 10.4103/0973-7847.79093.
An exponential increase in the number of studies investigating how different components of the diet interact at the molecular and cellular level to determine the fate of a cell has been witnessed. In search for anticancer drugs compelling data from laboratories, epidemiologic investigations, and human clinical trials showed that flavonoids have important effects on cancer chemoprevention and chemotherapy. In many molecular mechanisms of action for prevention against cancer, flavonoids play a major role by interacting between different types of genes and enzymes. Many mechanisms of action have been identified, including carcinogen inactivation, antiproliferation, cell cycle arrest, induction of apoptosis, inhibition of angiogenesis, antioxidation, and reversal of multidrug resistance or a combination of these mechanisms. This review focuses on the anticancer activity of flavonoids as well as their molecular mechanisms, including the treatment of mammary and prostate cancer. This review also highlights some advanced derivatives of flavonoids, which play an important role against cancer.
我们已经见证了，研究饮食中不同成分如何在分子和细胞水平相互作用以决定细胞命运的研究数量呈指数级增长。在寻找抗癌药物的过程中，来自实验室、流行病学调查和人体临床试验的有力数据表明，黄酮类化合物对癌症化学预防和化疗具有重要作用。在许多预防癌症的分子作用机制中，黄酮类化合物通过不同类型的基因和酶之间的相互作用发挥主要作用。已经确定了许多作用机制，包括致癌物失活、抗增殖、细胞周期停滞、诱导凋亡、抑制血管生成、抗氧化以及逆转多药耐药性或这些机制的组合。本综述重点关注黄酮类化合物的抗癌活性及其分子机制，包括对乳腺癌和前列腺癌的治疗。本综述还强调了一些黄酮类化合物的先进衍生物，它们在抗癌方面发挥着重要作用。
