Lai Deng-Pan, Wang Jian-Feng, Yao Ju-Ping, Wang Yi-Fen, Cheng Guo-Qin
Emergency Department of the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2011 Jun;29(6):440-2.
To explore the effect of hemoperfusion(HP) about the patients of methamidophos poisoning.
On the basis of comprehensive treatment,15 cases of severe acute methamidophos poisoning patients were treated with HP, Blood samples were collected at 7 time points, before and 5, 15, 30, 45, 60mins following the beginning and the end of hemoperfusion. Blood samples were used for measuring the concentration of methamidophos and perfusion devices were used for measuring the volume of methamidophos adsorbed by the device after hemoperfusion.
15 patients live in 12 cases, 3 cases of death. HP (former) blood Cholinesterase vigor were 662.60 + 632.05, HP (after) blood cholinesterase vigor were 2577.52 + 920.38 IU/L; The difference of blood Cholinesterase vigor between the before and after HP was statistically significant (P < 0.01). The patients' methamidophos concentration of blood when HP treated 45, 60, 120 min were respectively (851 + 672), (680 + 529), (587 + 520) microg /ml, there were significantly lower than that the patients' methamidophos concentration of blood who were before HP (1659 + 1105) microg/ml, a statistically significant difference (P < 0.01).
HP can be cut down obviously methamidophos poisoning patients serum concentrations of toxic, the experimental method directly prove the clinical application of carbon HP can really adsorption methamidophos.
探讨血液灌流（HP）对甲胺磷中毒患者的治疗效果。
在综合治疗基础上，对15例重度急性甲胺磷中毒患者进行血液灌流治疗，于血液灌流开始前、开始后5、15、30、45、60分钟及结束后共7个时间点采集血样，用于测定甲胺磷浓度；血液灌流结束后，用灌流装置测定其对甲胺磷的吸附量。
15例患者中12例存活，3例死亡。血液灌流前血胆碱酯酶活力为662.60±632.05，血液灌流后血胆碱酯酶活力为2577.52±920.38IU/L；血液灌流前后血胆碱酯酶活力差异有统计学意义（P<0.01）。血液灌流治疗45、60、120分钟时患者血甲胺磷浓度分别为（851±672）、（680±529）、（587±520）μg/ml，明显低于血液灌流前患者血甲胺磷浓度（1659±1105）μg/ml，差异有统计学意义（P<0.01）。
血液灌流能明显降低甲胺磷中毒患者血清中毒物浓度，本实验方法直接证明了临床应用的活性炭血液灌流确实能吸附甲胺磷。
