Lai Deng-pan, Ren Xian-hua, Yao Ju-ping, Liu Mao-lin, Xu Gang, Chen Zhao-jun, Ling Gui-lan
Emergency Department of The Affiliated Hospital of Hangzhou Normal University Hangzhou 310015, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012 Apr;30(4):310-2.
To explore the effect of hemoperfusion (HP) on tylenol poisoned patients.
Urgently established the blood access by transfemoral catheterization of femoral vein, we used charcoal hemoperfusion by blood pump and dynamically monitored the plasma concentration of tylenol active ingredients for the 2 patients and the content of tylenol active ingredients in the charcoal was determined.
Plasma concentration of tylenol active ingredients of the 2 patients was declined gradually during and after the HP management. The acetaminophen serum concentration of the case 1 was declined from the 13.4 µg/L at the start of HP to the 5.81 µg/L at the end of HP; and the case 2 was declined from 51.1 µg/L to 22.3 µg/L. The adsorption amount of acetaminophen in the blood perfusion device are respectively 119 542 µg of case 1 and 33 2154 µg of case 2.
Early hemoperfusion should be carried out for acute tylenol poisoning patients if there were indications, hemoperfusion can clear the tylenol active ingredients and this is an effective measure to eliminate tylenol active ingredients.
探讨血液灌流（HP）对泰诺中毒患者的影响。
通过股静脉经皮穿刺紧急建立血液通路，使用血泵进行活性炭血液灌流，动态监测2例患者泰诺活性成分的血浆浓度，并测定活性炭中泰诺活性成分的含量。
2例患者在血液灌流治疗期间及治疗后，泰诺活性成分的血浆浓度逐渐下降。病例1的对乙酰氨基酚血清浓度从血液灌流开始时的13.4μg/L降至血液灌流结束时的5.81μg/L；病例2从51.1μg/L降至22.3μg/L。血液灌流装置中对乙酰氨基酚的吸附量分别为病例1的119542μg和病例2的332154μg。
急性泰诺中毒患者如有指征应尽早进行血液灌流，血液灌流可清除泰诺活性成分，是消除泰诺活性成分的有效措施。
