[髓过氧化物酶129 A/G基因多态性与冠状动脉疾病严重程度的相关性]
[Correlation between MPO 129 A/G polymorphism and severity of coronary artery disease].
作者信息
Hu Jun-ling, Xu Jian-bo, Zhou Xin, Jiang Tie-min, Li Yu-ming, Zhang Mei
机构信息
Graduate School of Tianjin Medical University, Tianjin 300070, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011 Aug;27(3):306-10.
OBJECTIVE
To explore the relationship between myeloperoxidase (MPO) 129 A/G promoter polymorphisms and the severity of coronary artery disease (CAD).
METHODS
The study enrolled 267 patients who had been diagnosed as coronary artery diseases by coronary angiography. The serum MPO activity was detected by colorimetric method. PCR-RFLP method was used to decide the genotypes of the patients. The severity of CAD was evaluated by the numbers of stenotic coronary arteries and the Gensini scores respectively.
RESULTS
The MPO 129 locus G and A alleles frequency were 0.893 and 0.107, respectively. No significant difference was observed in serum MPO activity between different genotypes (P > 0.05). The distribution of genotypes in different Gensini score groups had no significant difference (P > 0.05). The patients with GG genotypes were prone to develop mutivessel diseases.
CONCLUSION
No significant correlation exists in MPO 129 locus polymorphism and serum MPO activity. The MPO 129 locus polymorphism isn't a reasonable predict factor of CAD severity.
目的
探讨髓过氧化物酶（MPO）129 A/G启动子多态性与冠状动脉疾病（CAD）严重程度之间的关系。
方法
本研究纳入267例经冠状动脉造影确诊为冠状动脉疾病的患者。采用比色法检测血清MPO活性。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法确定患者的基因型。分别通过狭窄冠状动脉数量和Gensini评分评估CAD的严重程度。
结果
MPO 129位点G和A等位基因频率分别为0.893和0.107。不同基因型之间血清MPO活性无显著差异（P>0.05）。不同Gensini评分组的基因型分布无显著差异（P>0.05）。GG基因型患者易患多支血管疾病。
结论
MPO 129位点多态性与血清MPO活性无显著相关性。MPO 129位点多态性不是CAD严重程度的合理预测因素。
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