Liu Shan-yun, He Yu-xiu, Zhang Hong-xia
Department of Health & Exercise Science, Tianjin University of Sport, Tianjin 300381, China.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011 Aug;27(3):315-8.
Based on high fat diet induced the model of atherosclerosis (AS) in C57BL/6J mice, authors studied the effect of endurance exercise on the atherosclerostic formation.
Forty eight 8-week-old C57BL/6J mice were divided into four groups randomly (n=12): control (group N), 12-week atherosclerosis model group(group H), 12-week atherosclerosis model plus 11-week treadmill training group (group H + E) and 22-week atherosclerosis model group (group HS). Then, we observed the effects of endurance exercise on the ultra structure of aorta by electron microscope.
Twenty weeks of high fat diet could result in serious AS in mice while endurance exercise could significantly antagonize or restrain the occur of AS. In addition, 10 weeks of endurance exercise could alleviate the symptom of pathological changes which already happened on aorta wall.
It indicated that endurance exercise could effectively prevent and cure AS that induced by high fat diet.
基于高脂饮食诱导C57BL/6J小鼠动脉粥样硬化（AS）模型，研究耐力运动对动脉粥样硬化形成的影响。
将48只8周龄C57BL/6J小鼠随机分为四组（n = 12）：对照组（N组）、12周动脉粥样硬化模型组（H组）、12周动脉粥样硬化模型加11周跑步机训练组（H + E组）和22周动脉粥样硬化模型组（HS组）。然后，通过电子显微镜观察耐力运动对主动脉超微结构的影响。
20周高脂饮食可导致小鼠严重AS，而耐力运动可显著对抗或抑制AS的发生。此外，10周耐力运动可缓解主动脉壁已发生的病理变化症状。
表明耐力运动可有效防治高脂饮食诱导的AS。
