Yan Hongyuan, Yang Gengliang
College of Pharmacy of Hebei University, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002, China.
Se Pu. 2011 Jul;29(7):572-9.
Due to the superior molecular recognition and good physical and chemical stability, the molecularly imprinted materials have gained more and more concern recently in extrication and separation fields. Using the imprinted materials as adsorbents, the molecularly imprinted solid-phase extraction (MISPE) allows selective extraction of the target molecules and its analogues from complex matrices, and is suitable for complex sample preparation and enrichment processes. This article describes the principle, latest progresses and parameters of molecularly imprinted solid-phase extraction and summarizes its extraction and applications for the determination of drug residues of animal source foods in recent years. Moreover, the shortcomings and future prospects of molecularly imprinted solid-phase extraction are also mentioned.
由于具有卓越的分子识别能力以及良好的物理和化学稳定性，分子印迹材料近年来在萃取和分离领域受到越来越多的关注。将印迹材料用作吸附剂，分子印迹固相萃取（MISPE）能够从复杂基质中选择性地萃取目标分子及其类似物，适用于复杂样品的制备和富集过程。本文介绍了分子印迹固相萃取的原理、最新进展和参数，并总结了其近年来在动物源食品药物残留测定中的萃取及应用情况。此外，还提及了分子印迹固相萃取的不足之处和未来前景。
