Department of Internal Medicine and Gastroenterology, Medical Hospital, The Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan.
J Gastroenterol Hepatol. 2011 Dec;26(12):1709-16. doi: 10.1111/j.1440-1746.2011.06890.x.
Ulcerative colitis (UC) is an immune disorder of the gastrointestinal tract which has been reported to be precipitated by interferon (IFN) therapy. We describe the results of a literature review of cases in which the development or exacerbation of UC was coincident with IFN and/or ribavirin (RIB) treatment for chronic hepatitis C. We summarized the studies on the effectiveness of IFN for UC or Crohn's disease, which were primarily carried out in Europe and the USA. In the nine reported cases of UC exacerbation by IFN therapy in Japan, seven involved IFN-α, one involved IFN-α2b plus RIB, and the other involved IFN-β; thus cases induced by IFN-α were more common. The period between the initiation of IFN treatment and the development or exacerbation of UC varied widely among the reported cases (from 1 day to 4.5 years). The reports have all assumed a cause-and-effect correlation between IFN treatment and UC. However, although combination therapy of IFN and RIB has become widespread in Japan, UC development or exacerbation induced by IFN has not increased concurrently. Conversely, numerous studies reporting the effectiveness of IFN for treating UC and Crohn's disease have been published in Europe and the USA. One reason for this finding may be the difference in the balance of T helper cell 1 and T helper cell 2 between populations.
溃疡性结肠炎（UC）是一种胃肠道免疫紊乱疾病，据报道，干扰素（IFN）治疗可诱发该病。我们对干扰素和/或利巴韦林（RIB）治疗慢性丙型肝炎时UC 发展或恶化的病例进行了文献复习，总结了 IFN 治疗 UC 或克罗恩病的有效性研究，这些研究主要在欧洲和美国进行。在日本报告的 9 例 IFN 治疗引起的 UC 恶化病例中，有 7 例与 IFN-α有关，1 例与 IFN-α2b 和 RIB 有关，另 1 例与 IFN-β有关；因此，IFN-α引起的病例更为常见。报告的病例中，从开始 IFN 治疗到 UC 发展或恶化的时间差异很大（从 1 天到 4.5 年）。这些报告都假定 IFN 治疗与 UC 之间存在因果关系。然而，尽管日本广泛采用 IFN 和 RIB 的联合治疗，但 IFN 诱导的 UC 发展或恶化并未同时增加。相反，在欧洲和美国发表了许多关于 IFN 治疗 UC 和克罗恩病有效性的研究报告。造成这种情况的一个原因可能是人群中辅助性 T 细胞 1 和辅助性 T 细胞 2 的平衡不同。
