Dermatology Clinic, Vesterbro 99, Aalborg, Denmark.
Int J Dermatol. 2011 Dec;50(12):1445-56. doi: 10.1111/j.1365-4632.2011.05104.x.
Systemic contact dermatitis is an inflammatory skin disease that may occur in persons with contact allergy when they are exposed to the hapten orally, transcutaneously, per rectum, intravesically, intravenously, or by inhalation. The most common causes of systemic contact dermatitis are drugs used both topically and systemically. Other causes are ubiquitously occurring haptens, such as the metals nickel, cobalt, gold, and chromate, and aromatic substances such as spices. Avoidance of the offending hapten is the most obvious treatment. For some haptens, such as nickel, diet treatment may be effective. Chelation therapy with disulfiram is another therapeutic option in nickel-allergic patients with systemic contact dermatitis. Hyposensitization therapy has been attempted with some success in systemic contact dermatitis caused by nickel and Parthenium hysterophorus.
系统性接触性皮炎是一种炎症性皮肤病，当接触过敏原经口、经皮、经直肠、经膀胱、经静脉或吸入时，接触过敏的人可能会发生。系统性接触性皮炎最常见的原因是局部和全身使用的药物。其他原因是普遍存在的半抗原，如金属镍、钴、金和铬酸盐，以及芳香物质，如香料。避免接触变应原是最明显的治疗方法。对于某些半抗原，如镍，饮食治疗可能有效。对于镍过敏的系统性接触性皮炎患者，二巯丁二酸螯合疗法是另一种治疗选择。免疫疗法已在镍和豚草引起的系统性接触性皮炎中取得了一定的成功。
