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接触性皮炎。

Contact dermatitis.

机构信息

Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.

CIRI - Centre International de Recherche en Infectiologie, INSERM, U1111; Univ Lyon; Université Claude Bernard Lyon 1; Ecole Normale Supérieure de Lyon; CNRS, UMR, 5308, Lyon, France.

出版信息

Nat Rev Dis Primers. 2021 May 27;7(1):38. doi: 10.1038/s41572-021-00271-4.

Abstract

Contact dermatitis (CD) is among the most common inflammatory dermatological conditions and includes allergic CD, photoallergic CD, irritant CD, photoirritant CD (also called phototoxic CD) and protein CD. Occupational CD can be of any type and is the most prevalent occupational skin disease. Each CD type is characterized by different immunological mechanisms and/or requisite exposures. Clinical manifestations of CD vary widely and multiple subtypes may occur simultaneously. The diagnosis relies on clinical presentation, thorough exposure assessment and evaluation with techniques such as patch testing and skin-prick testing. Management is based on patient education, avoidance strategies of specific substances, and topical treatments; in severe or recalcitrant cases, which can negatively affect the quality of life of patients, systemic medications may be needed.

摘要

接触性皮炎(CD)是最常见的炎症性皮肤病之一,包括过敏性 CD、光过敏性 CD、刺激性 CD、光刺激性 CD(也称为光毒性 CD)和蛋白 CD。职业性 CD 可属于任何类型,是最常见的职业性皮肤病。每种 CD 类型的特点是不同的免疫机制和/或必需的暴露。CD 的临床表现差异很大,多种亚型可能同时发生。CD 的诊断依赖于临床表现、彻底的暴露评估以及斑贴试验和皮肤点刺试验等技术的评估。治疗基于患者教育、避免接触特定物质的策略以及局部治疗;在严重或难治性病例中,可能会对患者的生活质量产生负面影响,可能需要全身性药物治疗。

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