Carnicle Jocelyn M, Tran Timothy V, McKissack Sterling S
Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas.
Department of Dermatology, William Beaumont Army Medical Center, El Paso, Texas.
Proc (Bayl Univ Med Cent). 2020 Aug 24;34(1):89-90. doi: 10.1080/08998280.2020.1805671.
Systemic contact dermatitis (SCD) describes a hypersensitivity skin reaction following systemic re-exposure of an allergen in previously sensitized patients. Neomycin is an aminoglycoside antibiotic that, when taken orally, suppresses intestinal bacteria and is used in preoperative bowel surgery to reduce the risk of infection. While oral neomycin has been commonly associated with adverse reactions like nausea, vomiting, and associated colitis, the poor intestinal absorption of oral neomycin makes systemic contact dermatitis an unusual adverse reaction. Herein we present a rare case of systemic contact dermatitis following oral neomycin administration.
系统性接触性皮炎（SCD）是指先前已致敏的患者再次全身性接触变应原后发生的一种超敏性皮肤反应。新霉素是一种氨基糖苷类抗生素，口服时可抑制肠道细菌，用于术前肠道手术以降低感染风险。虽然口服新霉素通常与恶心、呕吐及相关结肠炎等不良反应有关，但口服新霉素肠道吸收差，使得系统性接触性皮炎成为一种不常见的不良反应。在此，我们报告一例口服新霉素后发生系统性接触性皮炎的罕见病例。
