Wang Huiqin, Yang Yantao, Pei Gang, Wang Zhenzhen, Chen Naihong
Hunan University of Chinese Medicine and Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha, Hunan, China.
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica and Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Front Pharmacol. 2023 Apr 6;14:1182666. doi: 10.3389/fphar.2023.1182666. eCollection 2023.
Depression is a major neuropsychiatric disease that considerably impacts individuals' psychosocial function and life quality. Neurotrophic factors are now connected to the pathogenesis of depression, while the definitive neurotrophic basis remains elusive. Besides, phytotherapy is alternative to conventional antidepressants that may minimize undesirable adverse reactions. Thus, further research into the interaction between neurotrophic factors and depression and phytochemicals that repair neurotrophic factors deficit is highly required. This review highlighted the implication of neurotrophic factors in depression, with a focus on the brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), vascular endothelial growth factor (VEGF), and nerve growth factor (NGF), and detailed the antidepressant activities of various phytochemicals targeting neurotrophic factors. Additionally, we presented future opportunities for novel diagnostic and therapeutic strategies for depression and provided solutions to challenges in this area to accelerate the clinical translation of neurotrophic factors for the treatment of depression.
抑郁症是一种主要的神经精神疾病，严重影响个体的心理社会功能和生活质量。神经营养因子目前与抑郁症的发病机制相关，但确切的神经营养基础仍不清楚。此外，植物疗法是传统抗抑郁药的替代方法，可将不良副作用降至最低。因此，迫切需要进一步研究神经营养因子与抑郁症之间的相互作用以及修复神经营养因子缺陷的植物化学物质。本综述强调了神经营养因子在抑郁症中的意义，重点关注脑源性神经营养因子（BDNF）、胶质细胞系源性神经营养因子（GDNF）、血管内皮生长因子（VEGF）和神经生长因子（NGF），并详细阐述了针对神经营养因子的各种植物化学物质的抗抑郁活性。此外，我们还介绍了抑郁症新型诊断和治疗策略的未来机遇，并提供了该领域挑战的解决方案，以加速神经营养因子治疗抑郁症的临床转化。
