Gulati Shilpa, Agrawal Swati, Raghunandan Chitra, Bhattacharya Jayashree, Saili Arvind, Agarwal Shilpi, Sharma Deepika
Department of Obstetrics & Gynaecology, Lady Hardinge Medical College & Smt. Sucheta Kriplani Hospital, New Delhi, India.
J Matern Fetal Neonatal Med. 2012 Aug;25(8):1428-32. doi: 10.3109/14767058.2011.638952. Epub 2012 Feb 4.
To analyze the association of maternal serum interleukin-6 (IL-6) with fetomaternal outcome in preterm premature rupture of membranes (PPROM).
Serial serum IL-6 levels were measured in 45 women with PPROM at gestation 24-34 weeks. The women were followed till pueperium and fetomaternal outcome as well as the histopathology of the placenta and the umbilical cord was studied. The data were analyzed using t test and χ(2) test.
IL-6 levels ≥ 8 pg/ml were significantly associated with puerperal sepsis and neonatal sepsis. Histological chorioamnionitis and funisitis were demonstrated in 48.8% and 13.3% women respectively and significantly correlated with elevated serum IL-6 levels and fetomaternal infection. A cut-off value of IL-6 of 8 pg/ml was found to correctly diagnose 19 out of 23 patients with infectious morbidity and showed the best sensitivity (82.6%) and specificity (86.3%) as compared to the total leucocycte count (TLC) and C-reactive protein (CRP) in diagnosing infection in PPROM.
Maternal serum IL-6 can be used as a biomarker to predict preclinical asymptomatic infection in PPROM with good sensitivity and specificity.
分析母血白细胞介素-6（IL-6）与胎膜早破早产（PPROM）母婴结局的相关性。
对45例孕24 - 34周的PPROM孕妇连续检测血清IL-6水平。对这些孕妇进行随访直至产褥期，研究母婴结局以及胎盘和脐带的组织病理学。采用t检验和χ²检验分析数据。
IL-6水平≥8 pg/ml与产褥期败血症和新生儿败血症显著相关。分别有48.8%和13.3%的女性出现组织学绒毛膜羊膜炎和脐带炎，且与血清IL-6水平升高和母婴感染显著相关。发现IL-6的截断值为8 pg/ml时，能正确诊断23例感染性疾病患者中的19例，与总白细胞计数（TLC）和C反应蛋白（CRP）相比，在诊断PPROM感染方面显示出最佳的敏感性（82.6%）和特异性（86.3%）。
母血IL-6可作为一种生物标志物，以良好的敏感性和特异性预测PPROM临床前无症状感染。
