美国北卡罗来纳州 2010-11 年具有神经氨酸酶活性部位突变的乙型流感病毒。
Influenza B viruses with mutation in the neuraminidase active site, North Carolina, USA, 2010-11.
机构信息
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
出版信息
Emerg Infect Dis. 2011 Nov;17(11):2043-6. doi: 10.3201/eid1711.110787.
Abstract
Oseltamivir is 1 of 2 antiviral medications available for the treatment of influenza B virus infections. We describe and characterize a cluster of influenza B viruses circulating in North Carolina with a mutation in the neuraminidase active site that may reduce susceptibility to oseltamivir and the investigational drug peramivir but not to zanamivir.
摘要
奥司他韦是用于治疗乙型流感病毒感染的两种抗病毒药物之一。我们描述并分析了北卡罗来纳州流行的乙型流感病毒群，其神经氨酸酶活性部位的突变可能降低对奥司他韦和研究药物帕拉米韦的敏感性，但对扎那米韦没有影响。
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