Service de Neurologie, Centre Hospitalier Universitaire de Montréal (Hôpital Notre-Dame), 1560 rue Sherbrooke Est, Montréal (Québec) H2L 4M1, Canada.
Epilepsy Res. 2012 Mar;99(1-2):112-26. doi: 10.1016/j.eplepsyres.2011.10.035. Epub 2011 Nov 17.
Functional near-infrared spectroscopy (fNIRS) is a technique that allows continuous non-invasive monitoring of tissue oxygenation and haemodynamics in the brain. By using combined EEG-fNIRS recordings, we sought to better understand the pathophysiology of temporal lobe seizures.
Nine patients (5 males; mean age 35 years; range 11-56 years) with refractory mesial temporal lobe epilepsy underwent combined EEG-fNIRS recordings. Eight complex partial seizures from 3 patients were successfully recorded. All seizures were associated with significant local and remote haemodynamic changes which outlasted the duration of seizures. Over the epileptogenic temporal lobe, increased oxygenation [increase in cerebral blood volume (CBV) and oxyhaemoglobin (HbO), decrease in deoxyhaemoglobin (HbR)] was followed by a deoxygenated state [increase in HbR]. A similar haemodynamic profile was seen over the contralateral temporal lobe (even without evidence of epileptic propagation) though variations generally had lower amplitudes. Heterogeneous haemodynamic changes in remote frontal and/or parietal areas were also noted early on when epileptic activity was limited to the temporal lobe.
EEG-fNIRS reveals complex local and remote oxygenation changes during temporal lobe seizures.
功能近红外光谱（fNIRS）是一种可连续无创监测脑氧合和血液动力学的技术。通过使用 EEG-fNIRS 联合记录，我们试图更好地理解颞叶癫痫的病理生理学。
9 名（男性 5 名；平均年龄 35 岁；范围 11-56 岁）患有难治性内侧颞叶癫痫的患者接受了 EEG-fNIRS 联合记录。3 名患者的 8 例复杂部分性发作被成功记录。所有发作均伴有显著的局部和远程血液动力学变化，持续时间超过发作时间。在致痫性颞叶上，出现氧合增加（脑血容量 [CBV] 和氧合血红蛋白 [HbO] 增加，脱氧血红蛋白 [HbR] 减少），随后出现缺氧状态（HbR 增加）。在对侧颞叶也观察到类似的血液动力学特征（即使没有癫痫传播的证据），尽管变化幅度通常较低。当癫痫活动仅限于颞叶时，还早期注意到远程额部和/或顶叶区域的异质血液动力学变化。
EEG-fNIRS 揭示了颞叶癫痫发作期间复杂的局部和远程氧合变化。
