aza-黄酮类化合物作为有效的跨物种 microRNA 抑制剂，可阻止细胞周期。
aza-Flavanones as potent cross-species microRNA inhibitors that arrest cell cycle.
机构信息
Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India.
出版信息
Bioorg Med Chem Lett. 2012 Jan 1;22(1):645-8. doi: 10.1016/j.bmcl.2011.10.061. Epub 2011 Oct 24.
PMID:22100313
Abstract
aza-Flavanones have been identified as a new class of selective microRNA inhibitors. These compounds were found to arrest cell cycle via a novel cross species microRNA-dependent regulatory pathway interpreting an unexpected link between cell cycle arrest and microRNA mediated control in cancer.
摘要
aza-黄酮类化合物已被确定为一类新的选择性 microRNA 抑制剂。这些化合物通过一种新颖的跨物种 microRNA 依赖性调节途径来阻止细胞周期，该途径解释了细胞周期停滞和 microRNA 介导的癌症控制之间的意外联系。
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