Faculty of Engineering, Computing and Mathematics, The University of Western Australia, WA 6009, Australia.
Bone. 2012 Jan;50(1):378-89. doi: 10.1016/j.bone.2011.10.021. Epub 2011 Oct 30.
In this paper we develop a lattice-based computational model focused on bone resorption by osteoclasts in a single cortical basic multicellular unit (BMU). Our model takes into account the interaction of osteoclasts with the bone matrix, the interaction of osteoclasts with each other, the generation of osteoclasts from a growing blood vessel, and the renewal of osteoclast nuclei by cell fusion. All these features are shown to strongly influence the geometrical properties of the developing resorption cavity including its size, shape and progression rate, and are also shown to influence the distribution, resorption pattern and trajectories of individual osteoclasts within the BMU. We demonstrate that for certain parameter combinations, resorption cavity shapes can be recovered from the computational model that closely resemble resorption cavity shapes observed from microCT imaging of human cortical bone.
本文提出了一个基于晶格的计算模型，专注于单个皮质基本多细胞单位（BMU）中破骨细胞的骨吸收。我们的模型考虑了破骨细胞与骨基质的相互作用、破骨细胞之间的相互作用、破骨细胞从生长中的血管的产生以及核融合对破骨细胞核的更新。所有这些特征都强烈影响了正在发育的吸收腔的几何特性，包括其大小、形状和进展速度，并且还影响了 BMU 内单个破骨细胞的分布、吸收模式和轨迹。我们证明，对于某些参数组合，可以从计算模型中恢复与从人皮质骨的微 CT 成像观察到的吸收腔形状非常相似的吸收腔形状。
