Ait Oumghar Imane, Barkaoui Abdelwahed, Chabrand Patrick
Laboratoire des Energies Renouvelables et Matériaux Avancés (LERMA), Université Internationale de Rabat, Rabat-Sala El Jadida, Morocco.
Aix Marseille Univ, CNRS, ISM, Inst Movement Sci, Marseille, France.
Front Bioeng Biotechnol. 2020 Nov 2;8:584198. doi: 10.3389/fbioe.2020.584198. eCollection 2020.
A wide variety of bone diseases have hitherto been discovered, such as osteoporosis, Paget's disease, osteopetrosis, and metastatic bone disease, which are not well defined in terms of changes in biochemical and mechanobiological regulatory factors. Some of these diseases are secondary to other pathologies, including cancer, or to some clinical treatments. To better understand bone behavior and prevent its deterioration, bone biomechanics have been the subject of mathematical modeling that exponentially increased over the last years. These models are becoming increasingly complex. The current paper provides a timely and critical analysis of previously developed bone remodeling mathematical models, particularly those addressing bone diseases. Besides, mechanistic pharmacokinetic/pharmacodynamic (PK/PD) models, which englobe bone disease and its treatment's effect on bone health. Therefore, the review starts by presenting bone remodeling cycle and mathematical models describing this process, followed by introducing some bone diseases and discussing models of pathological mechanisms affecting bone, and concludes with exhibiting the available bone treatment procedures considered in the PK/PD models.
迄今为止，已发现多种骨疾病，如骨质疏松症、佩吉特病、骨硬化症和转移性骨病，这些疾病在生化和机械生物学调节因子变化方面尚无明确界定。其中一些疾病继发于其他病理状况，包括癌症或某些临床治疗。为了更好地理解骨骼行为并防止其恶化，骨生物力学一直是数学建模的主题，在过去几年中呈指数级增长。这些模型正变得越来越复杂。本文对先前开发的骨重塑数学模型，尤其是那些针对骨疾病的模型进行了及时且批判性的分析。此外，还介绍了包含骨疾病及其治疗对骨骼健康影响的机械药代动力学/药效学（PK/PD）模型。因此，本综述首先介绍骨重塑周期以及描述该过程的数学模型，接着引入一些骨疾病并讨论影响骨骼的病理机制模型，最后展示PK/PD模型中考虑的可用骨治疗程序。
