Zhang Le, Wang Zhihui, Sagotsky Jonathan A, Deisboeck Thomas S
Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA.
J Math Biol. 2009 Apr;58(4-5):545-59. doi: 10.1007/s00285-008-0211-1. Epub 2008 Sep 12.
Agent-based modeling (ABM) is an in silico technique that is being used in a variety of research areas such as in social sciences, economics and increasingly in biomedicine as an interdisciplinary tool to study the dynamics of complex systems. Here, we describe its applicability to integrative tumor biology research by introducing a multi-scale tumor modeling platform that understands brain cancer as a complex dynamic biosystem. We summarize significant findings of this work, and discuss both challenges and future directions for ABM in the field of cancer research.
基于主体的建模（ABM）是一种计算机模拟技术，正在社会科学、经济学等各种研究领域中得到应用，并且在生物医学中越来越多地作为一种跨学科工具来研究复杂系统的动态变化。在此，我们通过引入一个多尺度肿瘤建模平台来描述其在整合肿瘤生物学研究中的适用性，该平台将脑癌理解为一个复杂的动态生物系统。我们总结了这项工作的重要发现，并讨论了ABM在癌症研究领域面临的挑战和未来方向。
