Department of Advanced Research and Development, OrbusNeich Medical, Inc. 5363 NW 35th Ave, Fort Lauderdale, FL 33309, USA.
EuroIntervention. 2009 Dec 15;5 Suppl F:F65-71. doi: 10.4244/EIJV5IFA11.
The field of stent based tissue engineering continues to revolutionise modern medicine by designing novel materials to restore vascular tissue function. Accordingly, the following discussion examines a novel, absorbable, polymeric scaffold engineered in combination with dual therapeutic coating, enabling locally administered temporary scaffolding in the coronary arteries for long term vascular patency and repair. This coronary stent platform consists of an absorbable polymeric material stent structure that incorporates a dual partitioned coating, by means of pro-healing EPC (endothelial progenitor cell) capture technology allowing for rapid endothelial coverage, and an absorbable polymer matrix with sustained elution of sirolimus, a drug controlling neointimal proliferation. This paper provides a brief overview of the various innovations developed by OrbusNeich to create this fully absorbable coronary device platform.
支架基组织工程领域通过设计新型材料来恢复血管组织功能，继续推动现代医学的发展。因此，下面的讨论探讨了一种新型的、可吸收的聚合物支架，该支架与双治疗涂层相结合，可在冠状动脉内提供局部临时支架，以实现长期血管通畅和修复。这个冠状动脉支架平台由一个可吸收聚合物材料支架结构组成，该结构采用了双分区涂层，通过促进愈合的内皮祖细胞（endothelial progenitor cell，EPC）捕获技术，实现快速内皮覆盖，以及含有西罗莫司的可吸收聚合物基质，持续洗脱西罗莫司，以控制新生内膜增殖。本文简要介绍了 OrbusNeich 公司为创建这个完全可吸收冠状动脉器械平台而开发的各种创新技术。
