Centro de Neurociencias de Cuba, Avenida 25 y 158, Playa, La Habana, Cuba.
Neuroimage. 2012 Feb 15;59(4):3297-308. doi: 10.1016/j.neuroimage.2011.11.001. Epub 2011 Nov 10.
This paper extends previously developed 3D SPM for Electrophysiological Source Imaging (Bosch et al., 2001) for neonate EEG. It builds on a prior paper by our group that established age dependent means and standard deviations for the scalp EEG Broad Band Spectral Parameters of children in the first year of life. We now present developmental equations for the narrow band log spectral power of EEG sources, obtained from a sample of 93 normal neonates from age 1 to 10 months in quiet sleep. The main finding from these regressions is that EEG power from 0.78 to 7.5 Hz decreases with age and also for 45-50 Hz. By contrast, there is an increase with age in the frequency band of 19-32 Hz localized to parietal, temporal and occipital areas. Deviations from the norm were analyzed for normal neonates and 17 with brain damage. The diagnostic accuracy (measured by the area under the ROC curve) of EEG source SPM is 0.80, 0.69 for average reference scalp EEG SPM, and 0.48 for Laplacian EEG SPM. This superior performance of 3D SPM over scalp qEEG suggests that it might be a promising approach for the evaluation of brain damage in the first year of life.
本文扩展了之前为新生儿 EEG 开发的用于电生理源成像的三维 SPM（Bosch 等人，2001）。它基于我们小组的一篇先前的论文，该论文为生命第一年的儿童头皮 EEG 宽带谱参数建立了与年龄相关的均值和标准差。我们现在提出了来自 93 名正常新生儿在安静睡眠中 1 至 10 个月的窄带对数频谱功率的发育方程。这些回归的主要发现是，来自 0.78 到 7.5 Hz 的 EEG 功率随年龄而降低，45-50 Hz 也是如此。相比之下，在局部到顶叶、颞叶和枕叶的 19-32 Hz 频带中，随着年龄的增长而增加。对正常新生儿和 17 名脑损伤新生儿进行了异常值分析。脑电图源 SPM 的诊断准确性（通过 ROC 曲线下的面积来衡量）为 0.80，头皮 EEG SPM 的平均参考值为 0.69，而 Laplacian EEG SPM 为 0.48。3D SPM 优于头皮 qEEG 的性能表明，它可能是评估生命第一年脑损伤的一种有前途的方法。
