Key Laboratory of Molecular Biology for Infectious Disease, People's Republic of China Ministry of Education, Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.
Microbes Infect. 2012 Mar;14(3):262-7. doi: 10.1016/j.micinf.2011.10.003. Epub 2011 Oct 31.
XCL1, a C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses, whereas XCR1, the receptor of XCL1, is expressed by a dendritic cell subpopulation. The XCL1-XCR1 axis plays an important role in dendritic-cell-mediated cytotoxic immune response. It has been also shown that XCL1 and XCR1 are constitutively expressed in the thymus and regulate the thymic establishment of self-tolerance and the generation of regulatory T cells. This review summarizes the expression and function of XCL1 and XCR1 in the immune system.
XCL1，一种 C 类趋化因子，也被称为淋趋化因子，在感染和炎症反应期间由 T、NK 和 NKT 细胞产生，而 XCL1 的受体 XCR1，则由树突状细胞亚群表达。XCL1-XCR1 轴在树突状细胞介导的细胞毒性免疫反应中发挥重要作用。也已经表明，XCL1 和 XCR1 在胸腺中持续表达，调节自身耐受的胸腺建立和调节性 T 细胞的产生。这篇综述总结了 XCL1 和 XCR1 在免疫系统中的表达和功能。
